Peter Libby

Inflammation in atherosclerosis

Inflammation and Atherosclerosis

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Progress and challenges in translating the biology of atherosclerosis

Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine

Inflammation in Atherosclerosis

Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

Atherosclerosis

Diabetes and Atherosclerosis

From Vulnerable Plaque to Vulnerable Patient

The changing landscape of atherosclerosis

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

From Vulnerable Plaque to Vulnerable Patient

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

Inflammation in Atherosclerosis

The immune response in atherosclerosis: a double-edged sword

Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis

Molecular Bases of the Acute Coronary Syndromes

Pathophysiology of Coronary Artery Disease

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice

Current Concepts of the Pathogenesis of the Acute Coronary Syndromes

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

Mechanisms of Acute Coronary Syndromes and Their Implications for Therapy

Effect of Antihypertensive Agents on Cardiovascular Events in Patients With Coronary Disease and Normal Blood Pressure

Inflammation and cardiovascular disease mechanisms

Myocardial infarction accelerates atherosclerosis

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

COVID-19 is, in the end, an endothelial disease

Obesity, inflammation, and atherosclerosis

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Macrophages Facilitate Electrical Conduction in the Heart

Inflammation in Atherosclerosis: From Vascular Biology to Biomarker Discovery and Risk Prediction

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

Effect of Two Intensive Statin Regimens on Progression of Coronary Disease

Braunwald's heart disease

Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

Therapeutic siRNA silencing in inflammatory monocytes in mice

A guiding map for inflammation

Cardiovascular benefits and diabetes risks of statin therapy in primary prevention: an analysis from the JUPITER trial

Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

Inflammation in Atherosclerosis: Transition From Theory to Practice

Inflammation and plaque vulnerability

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

Chronic variable stress activates hematopoietic stem cells

Interleukins in cancer: from biology to therapy

A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism

The CD40/CD154 receptor/ligand dyadRID="†"ID="†" Review

Ischemia and No Obstructive Coronary Artery Disease (INOCA)

Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis

Cardiovascular remodelling in coronary artery disease and heart failure

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

Atherosclerosis and inflammation: overview and updates

Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes

An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions.

IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

Anti-Inflammatory Therapy With Canakinumab for the Prevention of Hospitalization for Heart Failure

Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms

Changing concepts of atherogenesis

Activated Interstitial Myofibroblasts Express Catabolic Enzymes and Mediate Matrix Remodeling in Myxomatous Heart Valves

Interleukin-1 Beta as a Target for Atherosclerosis Therapy

Inflammation and Thrombosis

Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.

The Aging Cardiovascular System

Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease

Inflammation and atherosclerosis: role of C-Reactive protein in risk assessment

Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis

An HMG-CoA Reductase Inhibitor, Cerivastatin, Suppresses Growth of Macrophages Expressing Matrix Metalloproteinases and Tissue Factor In Vivo and In Vitro

Generation of Biologically Active IL-1β by Matrix Metalloproteinases: A Novel Caspase-1-Independent Pathway of IL-1β Processing

Stabilization of atherosclerotic plaques: New mechanisms and clinical targets

IRF3 and type I interferons fuel a fatal response to myocardial infarction

CD40 Signaling and Plaque Instability

The Unstable Atheroma

Modulation of the interleukin-6 signalling pathway and incidence rates of atherosclerotic events and all-cause mortality: analyses from the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS)

Roles of Infectious Agents in Atherosclerosis and Restenosis

Lipid Lowering by Diet Reduces Matrix Metalloproteinase Activity and Increases Collagen Content of Rabbit Atheroma

Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis

Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases.

Cutting Edge: Heat Shock Protein (HSP) 60 Activates the Innate Immune Response: CD14 Is an Essential Receptor for HSP60 Activation of Mononuclear Cells

Inflammatory Mechanisms: The Molecular Basis of Inflammation and Disease

Chlamydial Heat Shock Protein 60 Localizes in Human Atheroma and Regulates Macrophage Tumor Necrosis Factor-α and Matrix Metalloproteinase Expression

Inflammation, Immunity, and Infection in Atherothrombosis

Ly-6C ^high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

Expression of Interleukin (IL)-18 and Functional IL-18 Receptor on Human Vascular Endothelial Cells, Smooth Muscle Cells, and Macrophages

Reassessing the Mechanisms of Acute Coronary Syndromes

Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.

Inflammation, Immunity, and HMG-CoA Reductase Inhibitors

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells

Fatty acid modulation of endothelial activation

Macrophages and atherosclerotic plaque stability

Acute Coronary Syndromes

Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle Cells

Extramedullary Hematopoiesis Generates Ly-6C ^high Monocytes That Infiltrate Atherosclerotic Lesions

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.

Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells

Soluble CD40L and Cardiovascular Risk in Women

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

Inflammation, Aging, and Cardiovascular Disease

Matrix Metalloproteinase Inhibition Attenuates Early Left Ventricular Enlargement After Experimental Myocardial Infarction in Mice

Sleep modulates haematopoiesis and protects against atherosclerosis

Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

Adiponectin: a key adipocytokine in metabolic syndrome

Macrophage-Derived Matrix Vesicles

Mast cells promote atherosclerosis by releasing proinflammatory cytokines

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure

Inflammation in Atherosclerosis

Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression

Atherosclerotic Vascular Disease Conference

Role of Inflammation in Atherosclerosis Associated with Rheumatoid Arthritis

Inflammation during the life cycle of the atherosclerotic plaque

High-Dose Atorvastatin Enhances the Decline in Inflammatory Markers in Patients With Acute Coronary Syndromes in the MIRACL Study

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

Optical coherence tomography in coronary atherosclerosis assessment and intervention

Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid

Lysosomal Cysteine Proteases in Atherosclerosis

Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis.

Endothelial function and coronary artery disease

Soluble CD40L

TLR2 and neutrophils potentiate endothelial stress, apoptosis and detachment: implications for superficial erosion

Neutrophil extracellular traps: from physiology to pathology

Statins Alter Smooth Muscle Cell Accumulation and Collagen Content in Established Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

Novel Inflammatory Markers of Coronary Risk

The Forgotten Majority

Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

Neutrophil Extracellular Traps Participate in Cardiovascular Diseases

Coronary Artery Reperfusion

Precordial S-T segment elevation mapping: An atraumatic method for assessing alterations in the extent of myocardial ischemic injury

Chronic Rejection

Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis

Inflammation and Immunity in Diseases of the Arterial Tree

<i>TET2</i>-Driven Clonal Hematopoiesis and Response to Canakinumab

Vascular biology of atherosclerosis: overview and state of the art

The neutrophil–lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials

COVID-19 – A vascular disease

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice

Expression of Neutrophil Collagenase (Matrix Metalloproteinase-8) in Human Atheroma

Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice

Implantation of Vascular Grafts Lined with Genetically Modified Endothelial Cells

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events

Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1α and Cathepsin G

Regulation of Matrix Metalloproteinase Expression in Human Vascular Smooth Muscle Cells by T Lymphocytes

Ferritinophagy and ferroptosis in the management of metabolic diseases

Human vascular smooth muscle cells. Target for and source of tumor necrosis factor.

Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

Production of Platelet-Derived Growth Factor–like Mitogen by Smooth-Muscle Cells from Human Atheroma

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.

Hypoxia But Not Inflammation Augments Glucose Uptake in Human Macrophages

Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosis

Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study

The Stromal Cell–Derived Factor-1 Chemokine Is a Potent Platelet Agonist Highly Expressed in Atherosclerotic Plaques

Inflammation in Atherosclerosis—No Longer a Theory

Atherosclerosis

Inflammation in acute myocardial infarction: the good, the bad and the ugly

Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice

Atherosclerosis: The New View

Evidence for Altered Balance Between Matrix Metalloproteinases and Their Inhibitors in Human Aortic Diseases

Apolipoprotein CIII Induces Expression of Vascular Cell Adhesion Molecule-1 in Vascular Endothelial Cells and Increases Adhesion of Monocytic Cells

Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease

Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia.

Roles of PAD4 and NETosis in Experimental Atherosclerosis and Arterial Injury

Effect of Glucose-Insulin-Potassium Infusion on Myocardial Infarction following Experimental Coronary Artery Occlusion

Adaptive immunity and atherosclerosis

Requiem for the ‘vulnerable plaque’

Reduction of Experimental Myocardial Infarct Size by Corticosteroid Administration

Progression of Atheroma

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

Intertwining of thrombosis and inflammation in atherosclerosis

From Focal Lipid Storage to Systemic Inflammation

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Inhibition of Interleukin-1β by Canakinumab and Cardiovascular Outcomes in Patients With Chronic Kidney Disease

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue

Circumferential Stress and Matrix Metalloproteinase 1 in Human Coronary Atherosclerosis

Enhanced Expression of Vascular Matrix Metalloproteinases Induced <i>In Vitro</i> by Cytokines and in Regions of Human Atherosclerotic Lesions^a

Report of the National Heart, Lung, and Blood Institute-National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Cardiovascular Complications of Type 1 Diabetes Mellitus

Vascular Remodeling in Transplant Vasculopathy

Fas Is Expressed in Human Atherosclerotic Intima and Promotes Apoptosis of Cytokine-Primed Human Vascular Smooth Muscle Cells

Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury.

Mucosal Administration of Heat Shock Protein-65 Decreases Atherosclerosis and Inflammation in Aortic Arch of Low-Density Lipoprotein Receptor-Deficient Mice

Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

<i>The American Journal of Cardiology</i> and <i>Journal of Periodontology</i> Editors' Consensus: Periodontitis and Atherosclerotic Cardiovascular Disease

The Nuclear Factor κ-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis

Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

A Fluorescent Probe for the Detection of Myeloperoxidase Activity in Atherosclerosis-Associated Macrophages

Circulating Cell Adhesion Molecules Are Correlated With Ultrasound-Based Assessment of Carotid Atherosclerosis

Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction

Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis

Cytokines in the Pathogenesis of Atherosclerosis

Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury

Spatiotemporal controlled delivery of nanoparticles to injured vasculature

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice.

The vulnerable atherosclerotic plaque

Clonal Hematopoiesis

Fish Oil and Postoperative Atrial Fibrillation

Residual inflammatory risk associated with interleukin-18 and interleukin-6 after successful interleukin-1β inhibition with canakinumab: further rationale for the development of targeted anti-cytokine therapies for the treatment of atherothrombosis

Mechanisms of plaque stabilization with statins

The molecular mechanisms of the thrombotic complications of atherosclerosis

Neutrophil Elastase in Human Atherosclerotic Plaques

Matrix Metalloproteinase-13/Collagenase-3 Deletion Promotes Collagen Accumulation and Organization in Mouse Atherosclerotic Plaques

Coronary Artery Calcification: Current Concepts and Clinical Implications

International Atherosclerosis Society guidance for implementing best practice in the care of familial hypercholesterolaemia

HMG CoA Reductase Inhibitors Reduce Plasminogen Activator Inhibitor-1 Expression by Human Vascular Smooth Muscle and Endothelial Cells

Human interleukin 1 induces interleukin 1 gene expression in human vascular smooth muscle cells.

Deficiency of the Cysteine Protease Cathepsin S Impairs Microvessel Growth

Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

Statins Reduce Inflammation in Atheroma of Nonhuman Primates Independent of Effects on Serum Cholesterol

Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management—The Plaque Hypothesis

Adiponectin Deficiency Increases Allergic Airway Inflammation and Pulmonary Vascular Remodeling

Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization

18F-4V for PET–CT Imaging of VCAM-1 Expression in Atherosclerosis

Molecular Imaging of Cardiovascular Disease

Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells

Indocyanine Green Enables Near-Infrared Fluorescence Imaging of Lipid-Rich, Inflamed Atherosclerotic Plaques

TH2 Predominant Immune Responses Prevail in Human Abdominal Aortic Aneurysm

CD40 Ligand Mediates Inflammation Independently of CD40 by Interaction With Mac-1

Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge–Mediated Monocyte Adhesion

INDUCIBLE EXPRESSION OF CLASS II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS AND THE IMMUNOGENICITY OF VASCULAR ENDOTHELIUM