John Q. Trojanowski

α-Synuclein in Lewy bodies

Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Diagnosis and management of dementia with Lewy bodies

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Diagnosis and management of dementia with Lewy bodies

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Second consensus statement on the diagnosis of multiple system atrophy

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

Alzheimer's Disease Neuroimaging Initiative (ADNI)

Neurodegenerative Tauopathies

Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

The Parkinson Progression Marker Initiative (PPMI)

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

The Alzheimer's Disease Neuroimaging Initiative

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Primary age-related tauopathy (PART): a common pathology associated with human aging

Alzheimer’s Disease Neuroimaging Initiative

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS

Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein

Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)

Chaperone Suppression of α-Synuclein Toxicity in a <i>Drosophila</i> Model for Parkinson's Disease

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Harnessing neuroplasticity for clinical applications

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly

Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

A harmonized classification system for FTLD-TDP pathology

Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with <i>SOD1</i> mutations

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

CSF biomarkers of Alzheimer's disease concord with amyloid‐β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts

Spreading of pathology in neurodegenerative diseases: a focus on human studies

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

The acetylation of tau inhibits its function and promotes pathological tau aggregation

Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

Gene expression changes in the course of normal brain aging are sexually dimorphic

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

Comparing predictors of conversion and decline in mild cognitive impairment

Protein transmission in neurodegenerative disease

Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease

The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans

At the interface of sensory and motor dysfunctions and Alzheimer's disease

Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

Synergistic Interactions between Aβ, Tau, and α-Synuclein: Acceleration of Neuropathology and Cognitive Decline

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

Astrocyte Senescence as a Component of Alzheimer’s Disease

The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

DLB and PDD boundary issues

TDP-43 in Familial and Sporadic Frontotemporal Lobar Degeneration with Ubiquitin Inclusions

Neuropathologic substrates of Parkinson disease dementia

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

Experimental Brain Injury Induces Regionally Distinct Apoptosis during the Acute and Delayed Post-Traumatic Period

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy

Clinical core of the Alzheimer's disease neuroimaging initiative: Progress and plans

Current state of Alzheimer’s fluid biomarkers

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

Plasma tau in Alzheimer disease

Mutant and Wild Type Human α-Synucleins Assemble into Elongated Filaments with Distinct Morphologies in Vitro

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

Epitopes that span the tau molecule are shared with paired helical filaments

Metabolic network failures in Alzheimer's disease: A biochemical road map

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

Frontotemporal dementia: Clinicopathological correlations

The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

Mechanisms of Parkinson's Disease Linked to Pathological α-Synuclein: New Targets for Drug Discovery

TAR DNA-binding protein 43 in neurodegenerative disease

Distribution patterns of tau pathology in progressive supranuclear palsy

Synucleinopathies

Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice

Relationships between biomarkers in aging and dementia

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration

A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

Progressive Atrophy and Neuron Death for One Year Following Brain Trauma in the Rat

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Clinicopathological correlations in corticobasal degeneration

NEURODEGENERATIVE DISEASES: New Concepts of Pathogenesis and Their Therapeutic Implications

Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions

TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia

Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein

Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

Sleep-disordered breathing advances cognitive decline in the elderly

Typical and atypical pathology in primary progressive aphasia variants

Comparing positron emission tomography imaging and cerebrospinal fluid measurements of β‐amyloid

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells.

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

Clinical Correlations With Lewy Body Pathology in<i>LRRK2</i>-Related Parkinson Disease

Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance

Increased F ₂ ‐isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation <i>in vivo</i>

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

Frontotemporal dementia and its subtypes: a genome-wide association study

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury

A yeast functional screen predicts new candidate ALS disease genes

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia

Total and phosphorylated tau protein as biological markers of Alzheimer’s disease

Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats

Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies

MRI and CSF biomarkers in normal, MCI, and AD subjects

CSF biomarker variability in the Alzheimer's Association quality control program

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Axonal transport defects: a common theme in neurodegenerative diseases

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

Neurodegeneration and defective neurotransmission in a <i>Caenorhabditis elegans</i> model of tauopathy

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

An acetylation switch controls TDP-43 function and aggregation propensity

Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans

Cerebrospinal Fluid Tau and β-Amyloid

Transplantation of Cryopreserved Human Embryonal Carcinoma-Derived Neurons (NT2N Cells) Promotes Functional Recovery in Ischemic Rats

Role of α-Synuclein Carboxy-Terminus on Fibril Formation in Vitro

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis

Proposed neuropathological criteria for the <i>post mortem</i> diagnosis of multiple system atrophy

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43

Increased 8,12-iso-iPF2?-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

The Molecular and Genetic Basis of Neurological Disease

Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

Distribution of tau proteins in the normal human central and peripheral nervous system.

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases

Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD

Pathological Heterogeneity of Frontotemporal Lobar Degeneration with Ubiquitin-Positive Inclusions Delineated by Ubiquitin Immunohistochemistry and Novel Monoclonal Antibodies

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical-hippocampal interactions

The future of blood‐based biomarkers for Alzheimer's disease

Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)

Clinicopathological correlations in behavioural variant frontotemporal dementia

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials

Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects

Evidence of Multisystem Disorder in Whole-Brain Map of Pathological TDP-43 in Amyotrophic Lateral Sclerosis

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration

α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies

Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer’s disease

Antibodies to ?-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease

Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation

Misfolded proteinase K–resistant hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

Frontotemporal dementia progresses to death faster than Alzheimer disease

TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

Guidelines for the standardization of preanalytic variables for blood‐based biomarker studies in Alzheimer's disease research

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis

Widespread Nitration of Pathological Inclusions in Neurodegenerative Synucleinopathies

PP2A mRNA Expression Is Quantitatively Decreased in Alzheimer's Disease Hippocampus

The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice

Phosphorylated α-Synuclein in Parkinson’s Disease

Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma

Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study

Concurrence of α-synuclein and tau brain pathology in the Contursi kindred

Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

TDP-43 Mediates Degeneration in a Novel<i>Drosophila</i>Model of Disease Caused by Mutations in VCP/p97

TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies

Poly(GP) proteins are a useful pharmacodynamic marker for <i>C9ORF72</i> -associated amyotrophic lateral sclerosis

Reversible Inhibition of α-Synuclein Fibrillization by Dopaminochrome-mediated Conformational Alterations

High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration

Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias

The cells of origin of the corpus callosum in rat, cat and rhesus monkey

Clinical and Pathological Continuum of Multisystem TDP-43 Proteinopathies

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration

A Lack of Amyloid β Plaques Despite Persistent Accumulation of Amyloid β in Axons of Long‐Term Survivors of Traumatic Brain Injury

Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy

Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

Accumulation of Amyloid β and Tau and the Formation of Neurofilament Inclusions Following Diffuse Brain Injury in the Pig

The Role of Calpail-Mediated Spectrin Proteolysis in Traumatically Induced Axonal Injury

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

<i>TMEM106B</i>, the Risk Gene for Frontotemporal Dementia, Is Regulated by the microRNA-132/212 Cluster and Affects Progranulin Pathways